(xylenes and 4-ethylbenzene)sulfonic acids

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

other: Read across from analogue substance

Adequacy of study:

key study

Study period:

1988

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

p-toluenesulfonic acid

IUPAC Name:

p-toluenesulfonic acid

Constituent 2

Reference substance name:

Toluene-4-sulphonic acid

EC Number:

203-180-0

EC Name:

Toluene-4-sulphonic acid

Cas Number:

104-15-4

Molecular formula:

C7H8O3S

IUPAC Name:

4-methylbenzene-1-sulfonic acid

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

Temp: 20 ± 3 °C
Relative humidity: 50 ± 20 %
Light: 12 hours
Food: ad libitum (Altromin 2123 Haultungsdiat supplied by Altromin-Gmbh)
Water: ad libitum tap water

Test system

Type of coverage:

semiocclusive

Preparation of test site:

shaved

Vehicle:

physiological saline

Controls:

yes, concurrent no treatment

Duration of treatment / exposure:

4 hour

Observation period:

7 days

Number of animals:

1

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

24 h

Score:

3

Max. score:

4

Reversibility:

not fully reversible within: 7 days

Results 2

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

48 h

Score:

4

Max. score:

4

Reversibility:

not fully reversible within: 7 days

Results 3

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

72 h

Score:

4

Max. score:

4

Reversibility:

not fully reversible within: 7 days

Results 4

Irritation parameter:

edema score

Basis:

animal #1

Time point:

24/48/72 h

Score:

2

Max. score:

4

Reversibility:

not fully reversible within: 7 days

Irritant / corrosive response data:

30-60 minutes after removing the plaster up to the 3rd day post administration, the skin of the animals showed a clearly circumscribed to severe erythema and a noticeable oedema. In addition, the skin surface was partly dry and brittle and flaky or brown over a large area. Hardening and scab formation were also observed. 7 days post administration the skin of the tier showed a clearly circumscribed erythema and a leitches odema. In addition, a dry and brittle skin surface, scab formation, an open wound and the formation of scars were observed.

Other effects:

Mean Edema score was 2.0, Brown discolouration

Any other information on results incl. tables

3 additional animals were exposed for 3 minutes each. The mean erythema score was 0.6 and the mean edema score was 0. Effect was reversible within 72 hours.

Washing immediately after exposure significantly reduced the severity and duration of the effect.

See attached table for details.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (corrosive) based on GHS criteria

Conclusions:

Skin Corrosion 1C, H314: Causes severe skin burns and eye damage.

Executive summary:

The skin irritation potential of Toluene 4-sulphonic acid was assessed following official guideline OECD 402, Acute Skin Irritation/Corrosion. The skin of the animals showed a clearly circumscribed to severe erythema and a noticeable oedema. In addition, the skin surface was partly dry and brittle and flaky or brown over a large area. Hardening and scab formation were also observed. The effects were seen after 7 days post administration.