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EC number: 701-247-3 | CAS number: -
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- other: estimated by modeling on related Hydrotropes category
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Estimations based on state of the science modelling, not measurement
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Principles of method if other than guideline:
- estimation by modelling
Test material
- Reference substance name:
- Hydrotropes
- IUPAC Name:
- Hydrotropes
- Details on test material:
- The HYDROTOPE Category comprises the following 6 substances:
STS - Sodium toluene sulphonate (CAS 657-84-1, EC 211-522-5)
SXS - Sodium (xylenes and 4-ethylbenzene) sulphonate (EC 701-037-1)
NH4XS - Ammonium (xylenes and 4-ethylbenzene) sulphonate (EC 943-024-5)
SCS - Sodium cumene sulphonate (CAS 15763-76-5, EC 239-854-6)
KCS - Potassium cumene sulphonate (CAS 164524-02-1, EC 629-764-9)
NH4CS - Ammonium cumene sulphonate (CAS 37475-88-0, 253-519-1)
In addition CaXS (Calcium Xylenesulphonate, CAS 28088-63-3, EC248-829-9) was evaluated for complete the assessment despite it is not registered under REACH.
Constituent 1
Results and discussion
Percutaneous absorption
- Key result
- Parameter:
- percentage
- Absorption:
- 2.8 %
- Remarks on result:
- other:
Any other information on results incl. tables
The modelling results show that the uptake of hydrotropes from either a diluted solution, or the concentrated product, into the stratum corneum, for short exposure durations varies between 0.36% and 0.55% of the amount applied.
- % dermal absorption is independent of concentration (i.e., the dermal flux is not saturated) and skin contact area
- % dermal absorption increases with duration exposure
- for all concentrations, the 23 hour uptake efficiency is ca 2.8% for this exposure scenario (it is unlikely if not inconceivable that anyone would be exposed to a solution containing a hydrotrope for 23 hours without removal and/or washing of the exposed surface; therefore the 2.8% uptake efficiency would represent an upper bound value)
- a 2.8% dermal absorption factor can therefore be used as an upper bound value in the exposure dose calculation
Applicant's summary and conclusion
- Conclusions:
- Based on state-of-science modelling, a 2.8% dermal absorption factor can be used as an upper bound value in exposure dose calculations for hydrotropes.
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