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EC number: 701-247-3
CAS number: -
Mortality: number of deaths at each dose: 2/5, 3/5 and 4/5 at 1250, 1600
and 2000 mg/kg for females, and 2/5 at 2000 mg/kg for males.
Time of death was Day 1 for all but one animal at 1600 mg/kg that died
on day 13.
Clinical signs: hypoactivity, hunched posture, irregular breathing were
observed in all animals from all dose groups on day 1 and was reversible
within 3 days for males at 2000 mg/kg. For females, the above symptoms
plus abnormal gait, ptosis and piloerection were seen in all animals at
1600 and 2000 mg/kg and were not reversible.
Necropsy findings: Red discolouration of the GI tract filled with blood,
white discolouration of the mucosa of the stomach and intestine, pale
adrenals, growing together of the stomach and nearby organs, stomach
haemorrhages and abdomen filled with fluid (in animals that died).
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