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EC number: 701-247-3
CAS number: -
Nominal Conc - 0, 4.6, 10, 22, 46, 100, 220 mg/L
Grow Rate Inhib (% of controls) - 0, -0.3, 1.0, -0.4, -1.3, 84, 98
Biomass Inhib (% of controls) - 0, 0.5, 5.9, 1.3, -4.6, 97, 100
Growth Factor Control - 27.6
The 72h NOEC is 44.8 mg/L active ingredient (a.i.) based on measured
Very possible that the effects observed at the highest test
concentrations are related to the acidity of the test substance.
The measured pH values at 0 and 72 hours were:
mg/L 0h 72h
0 8.1 9.3
4.6 8.0 9.3
10 7.7 9.2
22 7.2 9.2
46 6.8 9.2
100 5.0 5.2
220 3.1 3.0
NOEC for freshwater algae = 44.8 mg/L.
is a 2005 good quality "key study" for a 99.8% pure benzenesulfonic acid
(CAS No. 98-11-3). It followed OECD Guideline 201 and was done under GLP
with analytical confirmation and a reference substance. The 72h-EC50 for
Selenastrum capricornutum was 70 mg/L active ingredient based on biomass
inhibition. The 72h-EC50 was 73 mg/L for growth rate inhibition. The
reported 72h-NOEC was 44.8 mg/L. Both values are based on measured test
substance. It appears the pH of the test substance was responsible for
the observed toxicity. The report indicates that the observed toxicity
may very well have been due to the acidity of the test substance. The pH
of the test medium at the two highest test concentrations (100 and 220
mg/L) was in the range of 5 and 3, respectively.The test conditions were
confirmed to be valid and the measured concentrations were in the range
of 90-110% of the nominal concentrations for the 5 exposures
purposes, there are three guideline algal toxicity studies for the
hydrotropes (i. e., the salt form of the aromatic sulphonic acids) and
all three studies indicate toxicity in the same range as for the acid
The key study
is a 1993 USEPA Guideline study - EPA OTS 797.1500 - Algal Toxicity. The
study was not conducted with GLP requirements but considerable detail is
available. The freshwater Selenastrum sp. was exposed to a range of
nominal concentrations of the test substance, sodium xylene sulphonate
(CAS No 1300-72-7). The 96-hour EC50 was 230 mg/L active substance based
on cell density (with a 95% CL of 47-1200 mg/L). There was an apparent
dose response and the 96-hour NOEC was 31 mg/L. The test substance was
observed to be algistatic but not algicidal at the highest
concentration, 1000 mg/L active substance.
The 2nd study
is a 1994 EPA Guideline study (EPA OTS 797.1500) of calcium xylene
sulphonate (CAS No 28088-63-3) conducted under GLP requirements and with
analytical confirmation reports a 96h-EC50 of 758 mg/L active substance
(with a 95% confidence limit of 592-924 mg/L) and a NOEC of 240 mg/L
based on growth rate of Selenastrum sp.
The 3rd study
is a 1995 EU Guideline study (EU C.3 Algal Inhibition Test) of sodium
toluene sulphonate (CAS No 657-84-1 that is similar to CAS No
12068-03-3) conducted under GLP requirements and with analytical
confirmation reports a 72h-EbC50 of 150 mg/L active substance based on
cell density and a 72h-ErC50 of 310 mg/L based on specific growth rate
of Scenedesmus sp. The 72h-NOEC is 40 mg/L active substance based on
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