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EC number: 701-247-3
CAS number: -
The ASA Category comprises the following 5 aromatic sulphonic acids:
TSA, Toluene-4-sulphonic acid (EC 203-180-0, CAS 104-15-4)
XSA, (Xylenes and 4-ethylbenzene) sulphonic acid (EC 701-247-3, CAS -) Former EC 246-839-8
CSA, p-cumene sulphonic acid (EC 240-210-1, CAS 16066-35-6)
BSA, Benzene sulphonic acid (EC 202-638-7, CAS 98-11-3)
HBSA, 4-hydroxybenzensulphonic acid (EC No. 202-691-6, CAS No. 98-67-9)
Skin and eye irritation potential was assessed with available test on ASA substances.
Regarding skin irritation, three tests were available on TSA. The GLP guideline study conducted in 1988 indicated corrosive properties after 4 hours of exposure; and the effects were not reversible after 7 days. 3-minute exposures followed by washing with water resulted in a much less severe effect that was reversible within 72 hours. Two further publications are available on BUA report (1991) which confirm the effect on skin but only some details are available. During the test on sensitisation the primary skin irritation effect of 0.01 -20% solutions of toluene-4-sulphonic acid monohydrate in 0.9% NaCl solution was studied. The animals was exposed 24 hours to an occlusive application. An irritation effect was only found with 20% toluene-4-sulphonic acid , but in a study by Loden et al (1985) with rabbits, without occlusion and after 4 hours, the same concentration in pure water solution caused burns.
Regarding eye irritation, there is only one study available on HBSA. The test was performed in 1962 and is a non-guideline study where a 65% solution hydroxyl benzene sulphonic acid was used as tested item. The results indicated corrosion of the eye even after 5 seconds of exposure. There was no reversibility indicated within 14 days.
All the ASA substance are strong acid with very low pH values. Based on the results of the available studies and due to the similarity among the category members it seems reasonable to consider all the ASA substances as corrosive to the skin and eye.
The skin irritation potential of Toluene 4-sulphonic acid was assessed with the evaluation in a test done for skin sensitisation and followed official OECD guideline. An irritation effect was only found with 20% PTSA: one clearly defined erithema and a hardly discernible oedema, and a very slight erythema on the second animal.
The skin irritation potential of Toluene 4-sulphonic acid was assessed with a test where each animal was treated simulteneously at 4 application sites. Four hours exposure to 0.5% of the test item solution only caused irritation in one of three animals, while concentrations of 20-60% caused necrosis with subsequent scar formation.
3 additional animals were exposed for 3 minutes each. The mean erythema
score was 0.6 and the mean edema score was 0. Effect was reversible
within 72 hours.
Washing immediately after exposure significantly reduced the severity
and duration of the effect.
See attached table for details.
The skin irritation potential of Toluene 4-sulphonic acid was assessed following official guideline OECD 402, Acute Skin Irritation/Corrosion. The skin of the animals showed a clearly circumscribed to severe erythema and a noticeable oedema. In addition, the skin surface was partly dry and brittle and flaky or brown over a large area. Hardening and scab formation were also observed. The effects were seen after 7 days post administration.
The eye irritation of Hydroxybenzene sulphonic acid was assessed with a test where 9 animals were exposed to 0.1 mL of the test substance for 5, 10 or 30 seconds (3 animals for each duration) and then eyes were rinsed. The Draize, Woodard and Calvery scoring system was used. Observations were at 1, 4, 24, 48, 72, 120 and 168 hours following exposure. Reversibility was determined up to 14 days post exposure. The test substance is corrosive to the eye even with short (i.e., 5-30 second) exposure.
Based on existing tests the substance is classificated following Regulation (CE) 1272/2008 as:
-Skin Corrosion 1C, H314: Causes severe skin burns and eye damage.
- Eye Damage 1, H318: Causes serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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