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EC number: 701-247-3
CAS number: -
EC50 for freshwater invertrebrates = 100 mg/L
There are 3 short-term acute studies with
Daphnia Magna. The key study is a 2005 Guideline (OECD 202) study with a
99.8% analyticaly pure benzenesulfonic acid (CAS No. 98-11-3) conducted
under GLPs. It is a well documented limit test with analytical
confirmation. There was no mortality or immobility observed at 100 mg/L
(nominal) / 103 mg/L measured. The test conditions were confirmed to be
valid and the reference substance produced expected results. The
48h-EC50 for 98-11-3 is reported as >100 mg/L.
The 2005 study with benzenesulfonic acid
is the only one of the three studies with sufficient details and
adherence to OECD guidelines to use to establish the 48h-EC50 of >100
mg/L. The other 2 studies give support to this endpoint value.
There is a 1995 supporting study conducted
following OECD 202 but without analytical confirmation and no
confirmation of GLP compliance. This limit test was conducted with a 65%
pure (in water) benzenesulfonic acid (CAS No, 98-11-3). There was no
toxicity observed and the 48h-EC50 is reported as >100 mg/L. There is
also a 1983 study of p-toluenesulfonic acid (CAS No. 104-15-4)
designated a "weight-of-evidence" study. There were multiple, nominal
test concentrations (5000, 1000, 100, 10 and 0), however, the exposure
duration was 24 hours instead of the required 48 hours. There was no
toxicity in the 0 and 10 mg/L exposures, 5% at 100 mg/L, 35% at 1000
mg/L and 10% at 5000 mg/L. There are insufficient details and no
plausible explanation for the lower toxicity at 5000 mg/L. The results
indicate the 24h-EC50 is above 1000 mg/L.
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