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EC number: 701-247-3 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- other: Read across from a member of the Hydrotropes category
- Adequacy of study:
- key study
- Study period:
- Manuscript received 24th February 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of Sodium Tosylate-35S by Rats and Dogs
- Author:
- Dreyfuss, J., Shekosky, J.M., Ross, J.J. Jr.
- Year:
- 1 971
- Bibliographic source:
- Toxicology and Applied Pharmacology, vol. 20, p. 548-551
Materials and methods
- Objective of study:
- excretion
- metabolism
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium toluene-4-sulphonate
- EC Number:
- 211-522-5
- EC Name:
- Sodium toluene-4-sulphonate
- Cas Number:
- 657-84-1
- Molecular formula:
- C7H7O3S.Na
- IUPAC Name:
- sodium 4-methylbenzenesulfonate
Constituent 1
- Specific details on test material used for the study:
- Sodium tosylate-35S (99% purity)
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- Single dose was administered.
Doses / concentrations
- Dose / conc.:
- 34.8 mg/kg bw/day (nominal)
- Remarks:
- Single dose.
- No. of animals per sex per dose / concentration:
- Two
Results and discussion
Main ADME results
- Type:
- excretion
- Results:
- Excretion of the unchanged parent substance: urine 82% of which 80% was excreted within the first 24 hours; Feces 13% of which the first 11.7% was excreted within the first 24 hours.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The substance is rapidly absorbed given that almost 85% of the substance was excreted in the urine within 24 hours of dosing.
- Details on excretion:
- The primary excretory pathway is urinary with 82 to 85% of the dose being elimited via this route.
Toxicokinetic parameters
- Key result
- Toxicokinetic parameters:
- half-life 1st: 75 minutes
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- Chromatographic analysis of excreta indicated that only the unaltered tosylate-35S moeity had been excreted. In none of the three solvent systems employed was the presence of any metabolite detected.
Applicant's summary and conclusion
- Conclusions:
- The substance is rapidly absorbed following oral gavage adminstration and then excreted unchanged primarily in the urine.
- Executive summary:
In a metabolism study the substance was administered to Sprage Dawley rats (2 animals/sex/dose) by oral gavage at a dose level of 34.8 mg/kg bw (single administration). Urine and feces were collected daily for 4 days. The substance was excreted unchanged primarily in the urine.
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