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EC number: 701-247-3
CAS number: -
test item, 4 -hydroxybenzenesulphonic acid,was
for prenatal developmental toxicity following OECD
There were no deaths of females during the study at
any dose of a.i. No adverse changes in health condition and no clinical
symptoms of intoxication were observed in maternal animals following
administration of the test item at any dose. Nor were there any
toxicologically significant treatment-related effects on body weight or
food consumption in maternal animals.
Macroscopic structure of examined organsof pregnant
females and reproduction parameters (number of females with live
foetuses, number of live and dead foetuses, early and late
resorptions),were unaffected by treatment with the test item.
Examination of the thyroid glands (absolute and
relative weight of thyroid gland, histological examination of thyroid
gland)did not reveal any changes associated with the application of the
Test item-related foetal mortality was not evident
at any dose level. Detailed necropsy of foetuses did not reveal an
increase of external and visceral variations and malformationsat any
dose of a.i..
Based on statistical evaluation of mean values of
foetal body weight, no significant growth retardation was detected in
Dead foetuses were observed during necropsy. One
dead foetus was observed at the lowest dose level (250 mg of a.i./kg
bw/day) and one dead foetus was observed at the highest dose level (1000
mg of a.i./kg bw/day). It is sporadical finding and dead foetuses can be
found also in historical control group.
on statistical evaluation of mean values of foetal body weight, no
significant growth retardation was detected in treated groups
The mean AGD and corrected AGD of male and female
foetuses in treated groups was not statistically significantly different
from the control group.
No statistically significant differences with
toxicological significance were recorded in number of foetuses and
litters during the statistical evaluation of skeletal findings.
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