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EC number: 200-315-5
CAS number: 57-13-6
The handling of urea by the human body is well characterised as it is a normal product of protein catabolism and is normally produced in large quantities.
Absorption of Urea as follows based on
physicochemical/toxicological data following ECHA guidance 7c (2017).
The substance isa solid material with molecular weight of
60.0556 g/mol and water solubility of 624000 mg/L at 20°C. The log Pow
is around -1.73 at 20°C and the mean particle size is 0.1-5 mm. The
vapour pressure is 1.2 x 10-5mmHb or 0.0016 Pa at 25°C. The
substance has no ionizable groups.
absorption: The molecular weight below 500g/mol, the absence
of ionisable groups, the hydrophilic properties and the particle size,
are in favor of oral absorption. When SC (subcutaneous) versus oral LD50values
were compared, a factor of 0.57-0.63 was reached. Based on these data,
an oral absorption of 60% is considered.
absorption: Based upon the solid state with high
particle size (not reaching the thoracic airways), low vapor pressure
and high water solubility, deposition in the lower airways is assumed
most unlikely and absorption by inhalation is considered to be
negligible. From a conservative viewpoint, a 10 % inhalation absorption
absorption: Based upon the low molecular weight, solid
state and low vapor pressure (not evaporating), and the fact that the
structure is not binding to skin molecules, dermal absorption is
possible. However, the high water solubility, log P <0 and absence of
irritation are not in favour of dermal absorption. Experimental data on
the absorption of urea across normal human skinin vitrois
reported to be up to 9.5%.From a realistic conservative viewpoint, a 10
% dermal absorption is considered.
Urea is produced in the body (liver) of mammals as a consequence
of normal physiological processes, primarily by the detoxification of
ammonia resulting from protein catabolism, via the urea cycle.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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