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EC number: 200-315-5
CAS number: 57-13-6
All rabbits were assigned an irritant score of 0 at all time points.
The primary skin irritation potential of urea (AD1006) was assessed in
three rabbits. 0.5 g moistened test substance was applied onto clipped
skin for 4 hours using a semi-occlusive dressing. Observations were made
at 1, 24, 48 and 72 hours after exposure.
No skin irritation was caused by 4 hours exposure to the test substance.
There was no evidence of a corrosive effect on the skin. The test
substance did not stain the treated skin. No symptoms of systemic
toxicity were observed, and no mortality was observed. All 3 rabbits
gained weight during the observation period. The test substance was
found to be non-irritating to the skin of rabbits, and therefore
according to Council Directive 67/548/EEC does not require
classification or labelling.
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