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EC number: 200-315-5
CAS number: 57-13-6
No evidence of toxicity was seen in this study at dose levels of up to
In a 12 -month carcinogenicity screening assay, C57BL/6 mice
(50/sex/group) were exposed to urea in the diet at concentrations of
4500, 9000 or 45000 ppm for 12 months. Five animals/sex/group were
sacrificed at the end of the 365-day exposure period and a comprehensive
list of tissues were investigated histopathologically; interim deaths
were similarly investigated. All remaining animals were sacrificed after
the 4-month recovery period and investigated histopathologically. There
were no signs of toxicity. Survival and bodyweights were unaffected by
treatment. Gross and microscopic pathology did not reveal any
treatment-related effects. It is concluded that urea is of very low
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