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EC number: 219-941-5
CAS number: 2579-20-6
In the examination of offspring, no changes attributed to the test
substance were noted in the number of offspring, live birth index, sex
ratio, viability index on Day 4, external features, clinical signs, body
weights, or necropsy findings.
A combined repeated dose toxicity and reproductive toxicity screening
study was conducted on the test substance
1,3-Bis(aminomethyl)cyclohexane (1,3-BAC). The study
was performed according to OECD test guideline 422, and in compliance
Male and female rats were dosed at levels 0 (vehicle control), 10, 60,
and 300 mg/kg bw/day of 1,3-BAC as a solution in water; males were dosed
for 42 days in total including the mating period, females were dosed
from 14 days before mating until day 4 of lactation. The
clinical and pathological effects on reproduction in both the parental
generation and the offspring were recorded.
The test substance had no effects on the reproductive parameters of the
parental animals, nor on the developmental parameters of the offspring. The
no observed effect level of 1,3-Bis(aminomethyl)cyclohexane for
reproductive / developmental toxicity was considered to be 300 mg/kg/day
in parental animals and offspring.
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