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EC number: 219-941-5
CAS number: 2579-20-6
A bacterial reverse mutation assay (Ames test) was conducted to
determine the potential for the test substance
1,3-Cyclohexanedimethanamine to cause gene mutation. The test was
conucted according to OECD test guideline 471 and official Japanese
guidelines, and in compliance with GLP. The test involved exposing
strains of Salmonella typhimurium (TA100, TA1535, TA1537, and TA98) and
one strain of Escherichia coli (WP2uvrA/pKM101) to a series of solutions
of the test substance in distilled water, by the preincubation method. A
preliminary test was conducted to determine the concentrations to be
investigated in the main tests, followed by the main test which was
performed in duplicate. In the main test, microbial toxicity
(cytotoxicity) was seen for each Salmonella strain at 1250 µg/plate and
at 2500 µg/plate for E. coli in the absence of S9 mix (metabolic
activation). Microbial toxicity was observed for all strains tested at a
concentration of 1250 µg/plate in the presence of S9 mix. None of the
strains tested, either in the presence or the absence of S9 mix /
metabolic activation showed a significant increase in the number of
revertant colonies relevant to the concurrent negative controls (a
two-fold increase was considered significant). The concurrent positive
control plates showed an increase in the number of revertant colonies
relative to the negative controls, and so the test was shown to be
valid. It was concluded that 1,3-Cyclohexanedimethanamine had not shown
any mutagenic activity under the test conditions used.
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