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EC number: 219-941-5
CAS number: 2579-20-6
A study was performed to assess the contact sensitisation potential of
the test material in the albino guinea pig. The study was performed in
compliance with the OECD Guidelines for Testing of Chemicals No. 406
"Skin Sensitisation" (adopted 17 July 1992) and Method B6 of Commission
Directive 92/69/EEC (which constitutes Annex V of Council Directive
Based on the results of sighting tests, the concentrations of test
material for the induction and challenge phases were selected as follows:
Intradermal Induction: 0.05% w/v in distilled water
Topical Induction: 5% v/v in distilled water
Topical Challenge: 2% and 1% v/v in distilled water
The test material produced a 0% (0 reactions / 10 animals) sensitisation
rate and was classified as a non-sensitiser to guinea pig skin. The test
material did not meet the criteria for classification as a sensitiser
according to EU labelling regulations.
Ten test and five control animals were used for the main study.
The test material produced a 0% (0 reactions / 10 animals)
sensitisation rate and was classified as a non-sensitiser to guinea pig
skin. The test material did not meet the criteria for classification as
a sensitiser according to EU labelling regultions.
Migrated from Short description of key information:
Sensitization test in Guinea Pigs (Magnusson-Kligman test) - not
sensitising (0/10 reactions found).
No evidence of sensitisation (delayed-contact hypersensitivity) was
found for 1,3 -BAC in an adjuvant-type test (Magnusson-Kilgmann test).
On the evidence of this study, there is no basis on which to classify
the test substance as a dermal sensitiser.
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