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EC number: 219-941-5
CAS number: 2579-20-6
Corrosive effects seen in albino rabbit following 3 minutes' dermal
exposure. Substance is therefore considered corrosive and eye
irritation studies subsequently considered unjustified.
A study was performed to assess the irritancy potential of the test
material to the skin of the New Zealand White rabbit. The method used
followed the recommendations of the OECD Guidelines for Testing of
Chemicals No. 404 "Acute Dermal Irritation/Corrosion" (adopted 17 July
1992) and Method B4 of Commission Directive 92/69/EEC (which constitutes
Annex V of Council Directive 67/548/EEC).
A single 3-minute semi-occluded application of the test material to the
intact skin of one rabbit produced corrosive effects.
4-hour and 1-hour semi-occluded applications of the test material to the
intact skin were therefore not investigated.
The results of observation of dermal symptoms at 3 minutes, 60 minutes
and 4 hours after application
are illustrated in Table 1. In rats, the skin surfaces changed
color (dark brown) and subcutaneous hemorrhage occurred from 1.5 minutes
after application; these lesions were further aggravated as they were
macroscopically judged to be necrosis after 3 minutes. The skin surfaces
manifested highly necrotic appearances after 60 minutes; namely, dark
red brown lesions were slightly dried and hardened.
In the observation of cut surfaces of the skin at 4 hours after
application, necrosis appeared throughout the entire dermal layers and
hemorrhage as severe as it reached the dorsal muscle.
Er=erythema; Ed= edema; H=hemorrhage; N=necrosis Severity: 0= normal; 1=
very mild; 2= mild; 3= moderate; 4=severe
Table. Primary irritative symptoms in the skin
Body Weight (g)
Crj Wistar rats (6 weeks)
A skin corrosive test founded on the standards of the United Nations was
performed in accordance with "the test methods and evaluation criteria
in the evaluation of danger of unkown substances" established by the
Maritime Techniques Safety Bureau, Ministry of Transport (December
1985), in order to determine whether or not 1,3 -BAC corresponded to a
corrosive substance (class 8) defined in the recommendations of the
United Nations concerning the transport of dangerous substances.
As a result, the test substance was judged in accordance with the
criteria of the International Maritime Organization (IMO) to corespond
to a corrosive substance defined in the recommendations of the United
Nations concerning the transport of dangerous substances.
A primary skin irritation test was conducted on albino rabbits to
compare and determine the strength of primary skin irritation of
MXDA-based epoxy resin hardeners. The test results showed corrosive skin
lesions induced by 1,3 -BAC.
Three studies have been reported, all of which indicate the corrosive
nature of the substance.
The key study (SafePharm 1998) was conducted to OECD 404 and under GLP,
and showed skin corrosion.
A second study (Niigata Laboratories, 1986) was conducted according to
UN methods for skin corrosion and also shows corrosive effects.
A third study (Niigata Laboratories, 1984) was a skin irritation study
which also showed irritant / corrosive effects.
The substance is therefore considered to be corrosive to both skin and
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Corrosive effects were reported following 3 minutes' exposure to the
skin of one rabbit; observation was carried out up to 1 hour after
exposure. On this basis, the classification according to CLP (EC
Regulation 1272/2008, employing the GHS system for classification) is
corrosive category 1A.
Note that when corrosive category 1A is applied according to CLP,
Irreversible effects on the eye Category 1 also applies.
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