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EC number: 201-535-4
CAS number: 84-51-5
The test substance 2-ethylanthraquinone is neither irritating nor corrosive to the skin and the eyes. Information on respiratory irritation is lacking.
Individual Scores – Rabbit Number and Sex
Total of 24, 48 and 72 hours
Mean Score of 24, 48 and 72 hours
A GLP-study was performed to assess the irritancy potential of the test
material to the skin of the New Zealand White rabbit. The method used
followed that described in the OECD TG No. 404.
A single 4-hour, semi-occluded application of the test material to the
intact skin of three rabbits produced incidents of very slight erythema
and an isolated incident of very slight oedema. The test material
produced a primary irritation index of 0.3 (out of 8) and was classified
as a mild irritant to rabbit skin. No corrosive effects were noted.
The test material can be classified as non-irritant according to
Regulation (EC) No 1272/2008 (CLP).
Individual and mean scores for cornea, iris and conjunctivae
Rabbit Number and Sex (Bodyweigh in kg)
Time after treatment
125 Male (2.64)
92 Female (3.12)
100 Female (3.01)
A study was performed to assess the irritancy potential of the test
material 2-ethylanthraquinone to the eye o f the New Zealand White
rabbit. The method used followed that described in the OECD TG 405.
A single application o f the test material to the non-irrigated eye of
three rabbits produced minimal to moderate conjunctival irritation.
Diffuse corneal opacity and iridial inflammation was confined to one
treated eye. All treated eyes appeared normal 72 hours after treatment
or on day 7.
The test material was classified as a mild irritant to the rabbit eye
according to a modified Kay and Calandra classification system. The test
material is classified as non-irritant to the rabbit eye according to
Regulation (EC) No 1272/2008 (CLP).
Two studies on the irritation potential of the test material to the skin
and eye are available each.
One skin irritation study was performed under GLP and followed OECD TG
No. 404 (Jones 1991). The other study was performed according to the
method of Draize (Lewis 1987). In both studies, very slight erythema
were observed which were fully reversible within 48 or 72 hours. In the
OECD study, an isolated incident of very slight oedema was produced
which was fully reversible within 24 hours.
One eye irritation study was performed under GLP and followed OECD TG
No. 405 (Jones 1991). Diffuse corneal opacity and iridial inflammation
was confined to one treated eye. All treated eyes appeared normal 72
hours after treatment or on day 7. The other eye irritation study
followed the method of Draize (Lewis 1987). One rabbit showed slight
redness of the conjunctivae and slight swelling of the chemosis on day
1. From day 2 on, no effects were observed in any of the treated rabbits.
In the skin irritation studies, the observed mean scores erythema/eschar
and oedema that were obtained from ratings at 24, 48 and 72 hours after
treatment were not exceeding 0.3 in all animals and thus were well below
2.3. All effects were fully reversible within 72 hours. The substance
has therefore not to be classified as irritating to the skin according
to Regulation (EC) No 1272/2008 (CLP).
In the eye irritation studies, the observed mean scores for 24, 48 and
72 hours were below 1 (corneal opacity, iritis) or 2 (conjuntival
redness, chemosis) and all effects were fully reversible within 7 days.
The substance has therefore not to be classified as irritating to the
eye according to Regulation (EC) No 1272/2008 (CLP).
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