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EC number: 201-535-4
CAS number: 84-51-5
Group Mean Data
The ability of the test item to produce damage to chromosomes or
aneuploidy when administered to rats was performed according to OECD TG
The micronucleus test was performed with only male rats using the oral
route. Groups of five rats were treated at the maximum tolerated dose of
400 mg/kg, with 200 and 100 mg/kg as the two lower dose levels and using
arachis oil as the vehicle. Animals were dosed twice at time 0 and 24
hours. Bone marrow was extracted and smear preparations were made and
stained. Polychromatic (PCE) and normochromatic (NCE) erythrocytes were
scored for the presence of micronuclei and PCE/NCE ratio was calculated
as an indicator for toxicity.
There was no evidence of any significant increases in the incidence of
micronucleated polychromatic erythrocytes in animals dosed with the test
item when compared to the vehicle control group and the test item was
considered to be non-genotoxic under the conditions of the test.
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