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EC number: 201-535-4
CAS number: 84-51-5
The aim of this GLP-study was to assess the acute oral toxicity of
2-ethylanthraquinone in male and female rats. The procedure used was in
accordance with OECD guideline 401. For this purpose, a single oral dose
of 2-ethylanthraquinone suspended in corn oil was given by stomach tube
to groups of five male and five female fasted rats. The dose level was
2000 mg/kg in males and females. The animals were weighed one day before
dosing, just prior to dosing and at 2, 7 and 14 days after dosing. Any
sign of intoxication occurring during the 14-day observation period was
recorded. Gross post-mortem examination was done on all rats that died
during the study and on the survivors at the end of the 14-day
observation period. One female rat died 7 days after dosing. None of the
male rats died within the 14-day observation period.
After oral administration of 2-ethylanthraquinone, males and females
showed small weight losses or reduced gains during the first few days
after dosing. Thereafter the rats grew with normal weight-gains, except
for the female rat that died. The clinical signs observed were mainly
indicative of effects on motor coordination (decreased locomotor
activity, abnormal gait and body posture), on autonomous nervous system
(decreased respiratory rate, respiratory difficulties, pilo-erection,
diarrhea), on central nervous system (positional passivity), on mood
(vocalization, irritability) and on muscle tone (paralysis, diminished
body tone). Time of onset of the first signs was within 1.5 hour after
dosing. All signs had disappeared in males 5 days after treatment and in
females 6 days after treatment, except for the female rat that died
during the observation period. Autopsy of the rat that died 7 days after
treatment showed slight staining round nose, dry faeces, absent thymus,
dark and enlarged adrenals and blood stained caecal contents. At autopsy
14 days after dosing, no abnormalities were observed in the surviving
The acute oral LD50 was established to be greater than 2000 mg/kg in
male and female rats. The substance does not to be classified for acute
oral toxicity according to Regulation (EC) No 1272/2008 (CLP).
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