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EC number: 215-231-4
CAS number: 1314-35-8
Toxic Signs: Toxic signs were observed at the 1000 mg/kg dose level
including soft feces, hypoactivity, rough haircoat and death at both the
24 and 48 hour timepoints (5 out of 12 died). Based on the high
mortality rate, the rest of the animals in this group were euthanized
and the bone marrow was not analyzed. One animal at the 500 mg/kg dose
developed soft feces, and animals at the 750 mg/kg dose level developed
soft feces, hypoactivity, rough haircoats, irregular respiration, and/or
recumbency. In addition, one animal died in the 750 mg/kg group.
No in vivo mammalian gene mutation
data of sufficient quality are available for tungsten trioxide (target
substance). However, in vivo mammalian gene mutation data are available
for sodium tungstate (source substance), which are used for read-across.
Due to lower water solubility and lower toxicity for the target
substance compared to the source substance, the resulting read-across
from the source substance to the target substance is appropriate as a
conservative estimate of potential toxicity for this endpoint. In
addition, read-across is appropriate because the classification and
labelling is more protective for the source substance than the target
substance, the PBT/vPvB profile is the same, and the dose descriptors
are, or are expected to be, lower for the source substance. For more
details, refer to the read-across category approach description in the
Category section of this IUCLID submission or Annex 3 of the CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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