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EC number: 215-231-4
CAS number: 1314-35-8
In a skin sensitisation study conducted on guinea pigs and according to
OECD 406, tungsten trioxide was deemed to be not sensitising.
All animals survived till the end of the study.
- Step 1: There were no significant differences in the mean body weights
between the animals of the test substance group and those of the control
group on Days 0 and 25.
- Step 2: There were no significant differences in the mean body weights
between the test substance group and the control group on Day 0. On Day
25 the mean body weight of the test substance group animals was
slightly, but statistically, higher than that of the control animals.
This was of no biological significance and was regarded as a random
Immediately after the beginning of all epicutaneous exposures
(inductions, challenge) the motor activities of all animals were
increased. This is due to the dressings which restrict the freedom of
movement. Soon afterwards the behaviour was regular again. Except of the
observations described above no abnormal behaviour or clinical signs
were detected during the experiment in the animals.
Skin reactions after the intradermal FCA administration
Cranial and caudal injection sites: Local irritations were observed in
all animals beginning on the day after the injections. The irritations
started with local erythema, which became more severe and led to
ulcerations. Lesions did not heal until the end of the study. These
local alterations are known effects of Freund's adjuvant.
Skin reactions after the first and the second induction exposure
All animals of both groups had severe erythema and oedema in the
interscapula region which were attributed to the effects of the adjuvant.
Although no study data specifically evaluating the potential respiratory
sensitisation effects are available, based on the lack of human case
reports indicating that tungsten trioxide is a respiratory sensitiser,
as well as negative responses observed in both the skin sensitisation
and skin irritation animal studies, tungsten trioxide is not likely to
be a respiratory sensitiser.
A skin sensitization test of sufficient quality and tested in accordance
with standard methodology was available for tungsten trioxide. The
results of this study showed that tungsten trioxide did not cause skin
sensitization in the Guinea Pig. Therefore, no classification is
required for the skin sensitization endpoint for tungsten trioxide. No
respiratory sensitisation studies are available for tungsten trioxide.
Therefore, classification cannot be made due to lack of data. However,
this endpoint is not required for REACH registration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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