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EC number: 215-231-4
CAS number: 1314-35-8
The following information is taken into account for any hazard / risk
assessment: No neurotoxicity data of sufficient quality are available
for tungsten trioxide (target substance). However, neurotoxicity data
are available for sodium tungstate (source substance), which are used
for read-across. Due to lower water solubility and lower toxicity for
the target substance compared to the source substance, the resulting
read-across from the source substance to the target substance is
appropriate as a conservative estimate of potential toxicity for this
endpoint. In addition, read-across is appropriate because the
classification and labelling is more protective for the source substance
than the target substance, the PBT/vPvB profile is the same, and the
dose descriptors are, or are expected to be, lower for the source
substance. For more details, refer to the read-across category approach
description in the Category section of this IUCLID submission or Annex 3
of the CSR.
The neurotoxicity potential of sodium tungstate is reported by two
publications by Sachdeva et al, 2015 and Radcliffe et al, 2009. An
inhalation study reported that sodium tungstate is not appreciably
transported via the olfactory pathway to the brain following a single
90-min exposure in rats, although this pathway is known to transport a
number of other metals (Radcliffe et al, 2009). Sodium tungstate
exposure was reported in one study to produced oxidative stress in
brains from rats exposed. However, the study did not elucidate and
correlate these oxidative changes with behavioral and functional
alterations (Sachdeva et al, 2015).
No neurotoxicity studies are available for tungsten trioxide. However,
data were available on sodium tungstate, which are used for read-across.
The sodium tungstate neurotoxicity studies are more investigative
reports conducted under no standard testing guidelines which limit their
usability for regulatory purposes. Based on this, none of the data from
these publications warrant any classification for sodium tungstate and
subsequently tungsten trioxide as neurotoxicants per CLP as more
information is needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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