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EC number: 215-231-4
CAS number: 1314-35-8
Reported statistics and error estimates (Cont'd):
Estimates of the EC50 concentration values and their 95% confidence
limits for immobilization data were calculated using the probit method
and Trimmed Spearman-Karber method. When the p value for Goodness of Fit
was >0.05 and there was no other evidence of questionable convergence,
the probit method was selected for reporting. When
this criterion was not achieved, the Trimmed Spearman-Karber method was
selected for reporting.
No aquatic invertebrates long-term toxicity data of sufficient quality
are available for tungsten trioxide (target substance). However, aquatic
invertebrates long-term toxicity data are available for sodium tungstate
(source substance), which are used for read-across. Due to lower water
solubility and lower toxicity for the target substance compared to the
source substance, the resulting read-across from the source substance to
the target substance is appropriate as a conservative estimate of
potential toxicity for this endpoint. In addition, read-across is
appropriate because the classification and labelling is more protective
for the source substance than the target substance, the PBT/vPvB profile
is the same, and the dose descriptors are, or are expected to be, lower
for the source substance. For more details, refer to the read-across
category approach description in the Category section of this IUCLID
submission or Annex 3 of the CSR.
Tungsten trioxide was not tested for chronic toxicity to invertebrates
and read-across to sodium tungstate was used for this endpoint. In a
reproduction test using Daphnia magna and testing sodium tungstate, the
21-day NOEC for reproduction and growth was found to be 44.2 mg/L sodium
tungstate/L or approximately 26 mg W/L). Read-across to sodium tungstate
is appropriate as sodium tungstate is of higher solubility under
simulated environmental conditions and has the same classification and
PBT profile as tungsten trioxide.
Due to similar or lower transformation/dissolution results for tungsten
trioxide (the target substance) than sodium tungstate (the source
substance), the resulting toxicity potential would also be expected to
be similar or lower, so read-across is appropriate. In addition,
read-across is justified because the classification and labeling is the
same or less severe for the target substance PBT/vPvB profile is the
same. Finally, the dose descriptors are, or are expected to be,
sufficiently similar or higher for the target substance, and read-across
to the source substance is adequately protective. For more details,
refer to the read-across category approach description in the Category
section of this IUCLID submission or Annex 3 of the CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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