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EC number: 215-231-4
CAS number: 1314-35-8
All animals survived till the end of the study.
- Step 1: There were no significant differences in the mean body weights
between the animals of the test substance group and those of the control
group on Days 0 and 25.
- Step 2: There were no significant differences in the mean body weights
between the test substance group and the control group on Day 0. On Day
25 the mean body weight of the test substance group animals was
slightly, but statistically, higher than that of the control animals.
This was of no biological significance and was regarded as a random
Immediately after the beginning of all epicutaneous exposures
(inductions, challenge) the motor activities of all animals were
increased. This is due to the dressings which restrict the freedom of
movement. Soon afterwards the behaviour was regular again. Except of the
observations described above no abnormal behaviour or clinical signs
were detected during the experiment in the animals.
Skin reactions after the intradermal FCA administration
Cranial and caudal injection sites: Local irritations were observed in
all animals beginning on the day after the injections. The irritations
started with local erythema, which became more severe and led to
ulcerations. Lesions did not heal until the end of the study. These
local alterations are known effects of Freund's adjuvant.
Skin reactions after the first and the second induction exposure
All animals of both groups had severe erythema and oedema in the
interscapula region which were attributed to the effects of the adjuvant.
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