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EC number: 215-231-4
CAS number: 1314-35-8
No aquatic invertebrate short-term toxicity data of sufficient quality
are available for tungsten trioxide (target substance). However, aquatic
invertebrate short-term toxicity data are available for sodium tungstate
(source substance), which are used for read across. Due to lower water
solubility and lower toxicity for the target substance compared to the
source substance, the resulting read-across from the source substance to
the target substance is appropriate as a conservative estimate of
potential toxicity for this endpoint. In addition, read-across is
appropriate because the classification and labelling is more protective
for the source substance than the target substance, the PBT/vPvB profile
is the same, and the dose descriptors are, or are expected to be, lower
for the source substance. For more details, refer to the read-across
category approach description in the Category section of this IUCLID
submission or Annex 3 of the CSR.
No immobilisation was observed at the saturation concentration of
tungsten trioxide under exposure conditions in an acute toxicity test;
therefore, a definitive EC50 could not be determined and read-across to
sodium tungstate is used for this endpoint. In a test using Daphnia and
testing sodium tungstate the EC50 observed was found to be greater than
the highest concentration tested (>163 mg sodium tungstate/L or
approximately 96 mg W/L).
Due to similar or lower transformation/dissolution results for tungsten
trioxide (the target substance) than sodium tungstate (the source
substance), the resulting toxicity potential would also be expected to
be similar or lower, so read-across is appropriate. In addition,
read-across is justified because the classification and labelling is the
same or less severe for the target substance PBT/vPvB profile is the
same. Finally, the dose descriptors are, or are expected to be,
sufficiently similar or higher for the target substance, and read-across
to the source subtance is adequately protective. For more details, refer
to the read-across category approach description in the Category section
of this IUCLID submission or Annex 3 of the CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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