Registration Dossier
Registration Dossier
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EC number: 201-245-8 | CAS number: 80-05-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study discussed in the EU RAR 2003
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 948
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute toxicity by skin penetration (exact site not reported) was determined in 15 rabbits. Rabbits were treated with a 2 g/kg dose of Bisphenol A (administered as a 20 ml/kg dose of a 10% suspension of Bisphenol A in propylene glycol) and the LD50 was estimated.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 4,4'-isopropylidenediphenol
- EC Number:
- 201-245-8
- EC Name:
- 4,4'-isopropylidenediphenol
- Cas Number:
- 80-05-7
- Molecular formula:
- C15H16O2
- IUPAC Name:
- 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- propylene glycol
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 000 mg/kg bw
- Remarks on result:
- other: 3/15 rabbits died and the authors concluded that the LD50 would be close to 3000 mg/kg
- Mortality:
- Three of 15 rabbits died after treatment.
Applicant's summary and conclusion
- Executive summary:
Acute toxicity by skin penetration (exact site not reported) was determined in 15 rabbits. Rabbits were treated with a 2 g/kg dose of Bisphenol A (administered as a 20 ml/kg dose of a 10% suspension of Bisphenol A in propylene glycol) and the LD50 was estimated. Three of 15 rabbits died after treatment and the estimated LD50 was close to 3000 mg/kg.
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