4,4'-isopropylidenediphenol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study discussed in the EU RAR 2003

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1948

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Acute toxicity by skin penetration (exact site not reported) was determined in 15 rabbits. Rabbits were treated with a 2 g/kg dose of Bisphenol A (administered as a 20 ml/kg dose of a 10% suspension of Bisphenol A in propylene glycol) and the LD50 was estimated.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

4,4'-isopropylidenediphenol

EC Number:

201-245-8

EC Name:

4,4'-isopropylidenediphenol

Cas Number:

80-05-7

Molecular formula:

C15H16O2

IUPAC Name:

4-[2-(4-hydroxyphenyl)propan-2-yl]phenol

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

propylene glycol

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 3 000 mg/kg bw

Remarks on result:

other: 3/15 rabbits died and the authors concluded that the LD50 would be close to 3000 mg/kg

Mortality:

Three of 15 rabbits died after treatment.

Applicant's summary and conclusion

Executive summary:

Acute toxicity by skin penetration (exact site not reported) was determined in 15 rabbits. Rabbits were treated with a 2 g/kg dose of Bisphenol A (administered as a 20 ml/kg dose of a 10% suspension of Bisphenol A in propylene glycol) and the LD50 was estimated. Three of 15 rabbits died after treatment and the estimated LD50 was close to 3000 mg/kg.