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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study discussed in the EU RAR 2003

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1948

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute toxicity by skin penetration (exact site not reported) was determined in 15 rabbits. Rabbits were treated with a 2 g/kg dose of Bisphenol A (administered as a 20 ml/kg dose of a 10% suspension of Bisphenol A in propylene glycol) and the LD50 was estimated.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-isopropylidenediphenol
EC Number:
201-245-8
EC Name:
4,4'-isopropylidenediphenol
Cas Number:
80-05-7
Molecular formula:
C15H16O2
IUPAC Name:
4-[2-(4-hydroxyphenyl)propan-2-yl]phenol

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
propylene glycol

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 3 000 mg/kg bw
Remarks on result:
other: 3/15 rabbits died and the authors concluded that the LD50 would be close to 3000 mg/kg
Mortality:
Three of 15 rabbits died after treatment.

Applicant's summary and conclusion

Executive summary:

Acute toxicity by skin penetration (exact site not reported) was determined in 15 rabbits. Rabbits were treated with a 2 g/kg dose of Bisphenol A (administered as a 20 ml/kg dose of a 10% suspension of Bisphenol A in propylene glycol) and the LD50 was estimated. Three of 15 rabbits died after treatment and the estimated LD50 was close to 3000 mg/kg.