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Ashby and Odom (2004) conducted immature rat uterotrophic assays according to OECD protocols (Kanno et al., 2003a; Kanno et al., 2003b) and examined uterine growth and gene expression in rats administered Bisphenol A orally over the dose range of 2 µg/kg/day to 800 mg/kg/day. Expression of three oestrogen-responsive uterine genes and two control genes was determined using real-time PCR. Increases in gene expression were observed over the uterotrophic dose range (approximately 200 to 800 mg/kg/day Bisphenol A) but not over the dose range of 2 to 20 mg/kg/day, in which there was no uterotrophic response and no increase in gene expression. Thus, the no effect level for uterotrophic activity of Bisphenol A coincided with the no transcriptional effect level for uterine gene expression.