Registration Dossier
Registration Dossier
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EC number: 201-254-7 | CAS number: 80-15-9
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study well documented, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity studies of certain organic peroxides and hydroperoxides
- Author:
- Floyd EP, Stokinger HE
- Year:
- 1 958
- Bibliographic source:
- Am Ind Hyg Assoc J 19: 205-212
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- α,α-dimethylbenzyl hydroperoxide
- EC Number:
- 201-254-7
- EC Name:
- α,α-dimethylbenzyl hydroperoxide
- Cas Number:
- 80-15-9
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-methyl-1-phenylethyl hydroperoxide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 7 weeks
- Frequency of treatment:
- three times weekly (monday, wednesday, friday)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
19 mg/kg (one-fifth of LD50)
Basis:
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
4/5 died; loss of weight; the pelage was coarse in most rats after first week of treatment
Applicant's summary and conclusion
- Conclusions:
- The repeated oral application of one-fith of LD50 of cumene hydroperoxide was toxic to rats
- Executive summary:
Cumene hydroperoxide (one-fifth of LD50) was given orally to rats three times weekly for seven weeks; 4/5 animals died; the rats lost weight and the pelage was coarse.
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