Registration Dossier
Registration Dossier
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EC number: 201-254-7 | CAS number: 80-15-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: collection of data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 952
Materials and methods
- Principles of method if other than guideline:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- α,α-dimethylbenzyl hydroperoxide
- EC Number:
- 201-254-7
- EC Name:
- α,α-dimethylbenzyl hydroperoxide
- Cas Number:
- 80-15-9
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-methyl-1-phenylethyl hydroperoxide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- other: undiluted or diluted in Dowanol 50B
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period:
- no data
- Number of animals:
- no data
Results and discussion
Any other information on results incl. tables
Material |
No. of applications |
Site |
Rating - Response |
100% |
2 |
Ear |
Moderate hyperemia, edema, necrosis |
100% |
1 |
Abdomen |
Severe edema and necrosis, slight denaturation |
10% sol. |
10 |
Ear |
Slight hyperemia, scaliness, crustation |
10% sol. |
4 |
Abdomen |
Severe hyperemia and edema, moderate necrosis |
1% sol. |
10 |
Ear |
Very slight hyperemia and scaliness |
1% sol. |
10 |
Abdomen |
Moderate hyperemia and scaliness |
0.1% sol. |
10 |
Ear |
Very slight hyperemia and scaliness |
0.1% sol. |
10 |
Abdomen |
Sight scaliness |
Applicant's summary and conclusion
- Conclusions:
- Cumene hydroperoxide undiluted and its strong solutions are severely irritating to the skin
- Executive summary:
Cumene hydroperoxide was tested for skin irritation in rabbits; the undiluted substance and its strong solutions were severely irritating causing hyperemia, edema and necrosis
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