Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-254-7 | CAS number: 80-15-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study well documented, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Hydrogen peroxide mutagenicity towards Salmonella typhimurium
- Author:
- Kensese SM, Smith LL
- Year:
- 1 989
- Bibliographic source:
- Teratog Carcinog Mutagen 9: 211-218
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- α,α-dimethylbenzyl hydroperoxide
- EC Number:
- 201-254-7
- EC Name:
- α,α-dimethylbenzyl hydroperoxide
- Cas Number:
- 80-15-9
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-methyl-1-phenylethyl hydroperoxide
- Details on test material:
- no data
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA97, TA98, TA100, TA102, TA1537, TA1538
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- no data
Results and discussion
Test results
- Genotoxicity:
- positive
Any other information on results incl. tables
Agar plate incorporation assay: positive to strain TA 102, TA 97, TA 100 and TA 1537
Liquid incubation assay: only weak mutagenicity to TA 1537 (positive effect completely abolished by catalase or superoxide dismutase)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive
Cumene hydroperoxide is positive in the standard plate incorporation test according to Ames - Executive summary:
Cumene hydroperoxide was tested in Salmonella TA 97, TA 98, TA 100, TA 102, TA 1535 and TA 1538 in the standard plate incorporation assay according to Ames and in a liquid incubation method without metabolic activation; the substance was positive in the standard Ames test to the strains TA 102, TA 97, TA 100 and TA 1535 and showed only weak mutagenicity in the liquid incubation test in TA 1537
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
