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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: collection of data

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Eye irritation was tested on rabbit. The test substance was instilled undiluted or in propylene glycol.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
α,α-dimethylbenzyl hydroperoxide
EC Number:
201-254-7
EC Name:
α,α-dimethylbenzyl hydroperoxide
Cas Number:
80-15-9
Molecular formula:
C9H12O2
IUPAC Name:
1-methyl-1-phenylethyl hydroperoxide
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: undiluted or diluted in propylene glycol
Controls:
not specified
Duration of treatment / exposure:
24 h
Observation period (in vivo):
24 h
Number of animals or in vitro replicates:
5

Results and discussion

Any other information on results incl. tables

0.005 ml undiluted chemical: severe corneal injury with iritis and necroid eylids; 5% solution: moderate corneal injury with iritis; 1% solution: no corneal injury

Overall evaluation: Grade 9, severe

Applicant's summary and conclusion

Conclusions:
Cumene hydroperoxyde caused severe eye irritation
Executive summary:

Cumene hydroperoxide was tested for eye irritation in rabbits; instillation of small amounts of undiluted substance caused severe eye irritation with corneal injury, iritis and necroid eyelids