Registration Dossier
Registration Dossier
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EC number: 201-254-7 | CAS number: 80-15-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: collection of data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Occlusive treatment of Albino rabbits, no further specification
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- α,α-dimethylbenzyl hydroperoxide
- EC Number:
- 201-254-7
- EC Name:
- α,α-dimethylbenzyl hydroperoxide
- Cas Number:
- 80-15-9
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-methyl-1-phenylethyl hydroperoxide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 0.10, 0.20, 2.0 ml/kg
- No. of animals per sex per dose:
- 2-4
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.126 mL/kg bw
- 95% CL:
- 0.077 - 0.206
- Remarks on result:
- other: cooresponds to 133.6 mg/kg bw
Any other information on results incl. tables
Dose (ml/kg) |
Dead/dosed |
Days to death |
Skin irritation |
Signs and/or symptoms of toxicity |
2.0 |
2/2 |
0,1 |
necrosis |
Anaesthesia, eyes dark at 1 h |
0.20 |
4/4 |
1,1,2,2 |
necrosis |
Prostate at 1 day |
0.1 |
1/4 |
2 |
necrosis |
Very lethargic at 1 day |
Gross pathology of victims: lungs, livers and spleens congested; kidneys very dark; livers nottled; bladders filled with bloody urine; in survivors no remarkable findings
Applicant's summary and conclusion
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information
- Conclusions:
- Cumene hydroperoxide was highly toxic following acute covered dermal application
- Executive summary:
Cumene hydroperoxide was tested for acute dermal toxicity in rabbits (skin penetration); the LD50 was 0.126 ml/kg (cooresponds to 133.6 mg/kg bw); the signs of toxicity were anaesthesia, prostate and lethargy
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