Registration Dossier
Registration Dossier
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EC number: 201-254-7 | CAS number: 80-15-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 4 weeks
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study report which meets basic scientific principles (doses not provided)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity studies of certain organic peroxides and hydroperoxides
- Author:
- Floyd EP, Stokinger HE
- Year:
- 1 958
- Bibliographic source:
- Am. In. Hyg. Assoc. J. 19: 205-212
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- 5 rats were exposed to 4 geometrically spaced dose levels. LD50 determined according to Weil (1952, 1953)
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- α,α-dimethylbenzyl hydroperoxide
- EC Number:
- 201-254-7
- EC Name:
- α,α-dimethylbenzyl hydroperoxide
- Cas Number:
- 80-15-9
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-methyl-1-phenylethyl hydroperoxide
- Details on test material:
- 73% purity (minimum); no further information available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- specific doses were not provided, 4 geometrically spaced dose levels that included 400 mg/kg because effects at this dose level were mentioned
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 382 mg/kg bw
Any other information on results incl. tables
Extensive urinary bleeding, death within 5 d, no weight loss
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Cumene hydroperoxide was tested for its acute oral toxicity in rats; the oral LD50 was approximately 382 mg/kg bw; extensive urinary bleeding was observed at doses of 400 mg/kg bw.
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