Registration Dossier
Registration Dossier
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EC number: 226-798-2 | CAS number: 5470-11-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
There are two reports conducted by subcutaneous and intraperitoneal injections route with mammalian animals and one report conducted with chicken embryos. Limited data is insufficient to conclude the developmental toxicity of Hydroxylamine hydrochloride.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Toxicity to reproduction: other studies
Additional information
Three reports were provided to assess the developmental toxicity of Hydroxylamine hydrochloride.
In the report conducted by JOHN M. DESESSO et al, 2000, five structurally related hydroxylamine-bearing chemicals including hydroxylamine hydrochloride were administered at equimolar doses to rabbits either by subcutaneous (8.55 mmol/kg) or intracoelomic (2.66 mmol/embryo) injection on gestational day 12. Cellular debris was obvious in forelimb buds from embryos treated with the hydroxylamine-bearing compounds; however, none of the amino compounds produced an early episode of embryonic cell death
In this study (Shakuntala Chaube and M. Lois Murphy, 1966), 6- to 8-week-old pregnant Wistar rats were given single intraperitoneal injections on day 9, 10, 11 or 12 of pregnancy. Doses of 47 to 59.3 mg/kg were lethal to 8/12 dams. The embryotoxic effect was attributed to the maternal toxicity.
Another report published by Springer-verlag, 1994 draw a conclusion that Hydroxylamine hydrochloride had a very weak teratogenic effect after administration to chicken embryos on days 6 to 13 of incubation.
Limited data cannot provide enough information to determine the developmental toxicity of Hydroxylamine hydrochloride.
Justification for classification or non-classification
Based on the available data, it is inconclusive to implement the classification for the developmental toxicity of hydroxylamine hydrochloride.
Additional information
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