Registration Dossier
Registration Dossier
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EC number: 226-798-2 | CAS number: 5470-11-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: abstracted from the summary published in the well-known publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Evaluations 6-Potential Health Hazards of Existing Chemicals-Hydroxylamine and its salts
- Author:
- Springer-Verlag, Berlin Heidelberg New York, London Paris Tokyo, Hong Kong Barcelona, Budapest
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Deviations:
- not specified
- Principles of method if other than guideline:
- Marked oedema and severe clouding of the cornea with a greasy surface layer were evident 1 hour after the instillation of 50 mg into the conjunctival sac of the rabbit eye (2 animals)
Test material
- Reference substance name:
- Hydroxylamine hydrochloride
- IUPAC Name:
- Hydroxylamine hydrochloride
- Test material form:
- not specified
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Duration of treatment / exposure:
- 1h
- Observation period (in vivo):
- 24h, 8 days
- Number of animals or in vitro replicates:
- 2 animals
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- other: For the entire period, a grey white discolouration of the conjunctiva and the nictitating membrane was present.
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- Marked oedema and severe clouding of the cornea with a greasy surface layer were evident 1 hour after the instillation of 50 mg into the conjunctival sac of the rabbit eye (2 animals). After 24 hours, oedema, marked clouding, ciliary injection and discharge were seen, and after 8 days marked oedema, marked clouding, iritis, ingrowing vessels and a staphyloma. For the entire period, a grey white discolouration of the conjunctiva and the nictitating membrane was present.
- Executive summary:
Marked oedema and severe clouding of the cornea with a greasy surface layer were evident 1 hour after the instillation of 50 mg into the conjunctival sac of the rabbit eye (2 animals). After 24 hours, oedema, marked clouding, ciliary injection and discharge were seen, and after 8 days marked oedema, marked clouding, iritis, ingrowing vessels and a staphyloma. For the entire period, a grey white discolouration of the conjunctiva and the nictitating membrane was present.
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