Registration Dossier
Registration Dossier
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EC number: 226-798-2 | CAS number: 5470-11-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: abstracted from the summary published in the well-known publication, contributing to assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- hydroxylamine hydrochloride
- IUPAC Name:
- hydroxylamine hydrochloride
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- other: locusts
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- male locusts
Administration / exposure
- Route of administration:
- other: abdominal injection
- Vehicle:
- N/A
- Details on exposure:
- 0.05 ml hydroxylamine hydrochloride as a 0.1 M solution (equivalent to 350 µg) for 36hr
- Duration of treatment / exposure:
- 36 hr
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.05 ml hydroxylamine hydrochloride as a 0.1 M solution (equivalent to 350 µg)
Basis:
nominal conc.
- Control animals:
- yes
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- positive
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- caused chromosome aberrations (breaks, fragmentation, bridge formation) in the spermatocytes
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): positive
It is concluded that hydroxylamine hydrochloride caused chromosome aberrations (breaks, fragmentation, bridge formation) in the spermatocytes based on the results given in this report. - Executive summary:
A single abdominal injection into male locusts of 0.05 ml hydroxylamine hydrochloride as a 0.1 M solution (equivalent to 350µg) caused chromosome aberrations (breaks, fragmentation, bridge formation) in the spermatocytes 36 hours later, effects which were not observed in the controls.
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