Registration Dossier
Registration Dossier
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EC number: 226-798-2 | CAS number: 5470-11-1
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Remarks:
- acute
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: abstracted from the summary published in the well-known publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- hydroxylamine hydrochloride
- IUPAC Name:
- hydroxylamine hydrochloride
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Details on exposure:
- a rabbit given a subcutaneous injection of 55 mg hydroxylamine hydrochloride/kg for 10 minutes
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 10 minutes
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
55 mg /kg
Basis:
analytical conc.
- No. of animals per sex per dose:
- one
- Control animals:
- not specified
Results and discussion
Results of examinations
- Behaviour (functional findings):
- effects observed, treatment-related
- Description (incidence and severity):
- clonic spasms, strychnine-type convulsions and nystagmus
- Details on results:
- A rabbit tested with hydroxylamine hydrochloride became restless and developed clonic spasms, strychnine-type convulsions and nystagmus within 10 minutes of treatment.
Effect levels
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Applicant's summary and conclusion
- Conclusions:
- It was concluded that the administration of very high doses of hydroxylamine hydrochloride (55 mg/kg) to warm-blooded animals led to paralysis of the entire central nervous system immediately after convulsions.
- Executive summary:
As early as 1889 it was reported that a rabbit given a subcutaneous injection of 55 mg hydroxylamine hydrochloride/kg became restless and developed clonic spasms, strychnine-type convulsions and nystagmus within 10 minutes of treatment. The author concluded that the administration of very high doses to warm-blooded animals led to paralysis of the entire central nervous system immediately after convulsions.
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