Hydroxylammonium chloride

Endpoint summary

Description of key information

LD50 (mice, 24h): 408 mg/kg for male and 419 mg/kg for female mice

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1994

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: abstracted from the summary published in the well-known publication

GLP compliance:

not specified

Species:

rat

Strain:

other: Sprague-Dawley

Sex:

not specified

Route of administration:

oral: unspecified

Sex:

not specified

Dose descriptor:

LD50

Effect level:

600 mg/kg bw

Based on:

act. ingr.

Clinical signs:

other: Strong convulsions were observed before death. All of the rats had damage to the spleen

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

an oral LD50 value of ca. 600 mg/kg was reported for Sprague-Dawley rats. Strong convulsions were observed before death. All of the rats had damage to the spleen.

Executive summary:

An oral LD50 value of ca. 600 mg/kg was reported for Sprague-Dawley rats. Strong convulsions were observed before death. All of the rats had damage to the spleen.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

The key study was reported by Hans Riemann, 1950, where 200, 300, 400, 500 and 600 mg hydroxylamine hydrochloride /kg was administered to the male and female mice. Oral LD50 values reported for mice include 408 mg/kg for male and 419 mg/kg for female mice. In this study, adequate design and detailed information can fulfill the scientific principles, so the study should be given more weight for the determination of acute toxicity of test substance.

As the supportive study (Springer-Verlag, 1994), there are two summaries without detailed documented. After oral administration to rats, the LD50(rat) was 192 (± 52) mg/kg. And another oral LD50 value of ca. 600 mg/kg was reported for Sprague-Dawley rats. Strong convulsions were observed before death. All of the rats had damage to the spleen.

Another LD₅₀of ≥127 mg/kg body weight was foundafter theintraperitoneal injectionroutein female CD1 mice, which is used to be a supportive information for acute toxicity ofhydroxylamine hydrochloride.

Justification for classification or non-classification

Based on the available data, Hydroxylamine hydrochloride can be classified as category 4 for the acute oral toxicity according to CLP (Regulation EC No. 1272/2008).