Registration Dossier
Registration Dossier
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EC number: 226-798-2 | CAS number: 5470-11-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: abstracted from the summary published in the well-known publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Evaluations 6-Potential Health Hazards of Existing Chemicals-Hydroxylamine and its salts
- Author:
- Springer-Verlag, Berlin Heidelberg New York, London Paris Tokyo, Hong Kong Barcelona, Budapest
- Year:
- 1 994
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Hydroxylamine hydrochloride
- IUPAC Name:
- Hydroxylamine hydrochloride
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 97 to 153 mg/kg body weight
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 127 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- Death of the mice after high doses similarly occurred within 10 minutes.
- Clinical signs:
- The methaemoglobin content increased to a maximum of 13 to 14%, but rapidly returned to normal (within 60 minutes)
Applicant's summary and conclusion
- Conclusions:
- LD50(female mice, intraperitoneal injection)>=127 mg/kg bw
- Executive summary:
An LD50 of 1.83 mmol/kg body weight( ≥127 mg/kg body weight) was found in female CD1 mice after intraperitoneal injection of the hydrochloride. Within 10 minutes of the administration of 97 to 153 mg/kg body weight, the methaemoglobin content increased to a maximum of 13 to 14%, but rapidly returned to normal (within 60 minutes). Death of the mice after high doses similarly occurred within 10 minutes.
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