Registration Dossier
Registration Dossier
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EC number: 226-798-2 | CAS number: 5470-11-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: abstracted from the summary published in the well-known publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Evaluations 6-Potential Health Hazards of Existing Chemicals-Hydroxylamine and its salts
- Author:
- Springer-Verlag, Berlin Heidelberg New York, London Paris Tokyo, Hong Kong Barcelona, Budapest
- Year:
- 1 994
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydroxylamine hydrochloride
- IUPAC Name:
- Hydroxylamine hydrochloride
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 600 mg/kg bw
- Based on:
- act. ingr.
- Clinical signs:
- other: Strong convulsions were observed before death. All of the rats had damage to the spleen
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- an oral LD50 value of ca. 600 mg/kg was reported for Sprague-Dawley rats. Strong convulsions were observed before death. All of the rats had damage to the spleen.
- Executive summary:
An oral LD50 value of ca. 600 mg/kg was reported for Sprague-Dawley rats. Strong convulsions were observed before death. All of the rats had damage to the spleen.
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