Registration Dossier
Registration Dossier
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EC number: 226-798-2 | CAS number: 5470-11-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: abstracted from the summary published in the well-known publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Evaluations 6-Potential Health Hazards of Existing Chemicals-Hydroxylamine and its salts
- Author:
- Springer-Verlag, Berlin Heidelberg New York, London Paris Tokyo, Hong Kong Barcelona, Budapest
- Year:
- 1 994
Materials and methods
Test material
- Reference substance name:
- Hydroxylamine hydrochloride
- IUPAC Name:
- Hydroxylamine hydrochloride
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- other: semi-occlusive and occlusive
- Duration of treatment / exposure:
- 15 minutes (semi-occlusive);
20 hours (occlusive); - Observation period:
- 1 week
- Number of animals:
- 2 rabbits
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- No irritation was seen after exposure for 1 or 5 minutes, but after 15 minutes a slight mottled redness occurred which was reversible after 1 week. After a 20-hour exposure, similar findings were recorded which were again reversible after 1 week.
- Executive summary:
An 80% aqueous preparation of hydroxylamine hydrochloride was applied to the clipped dorsal skin of 2 rabbits (White Viennese) for1，5 or 15 minutes (semi-occlusive) or 20 hours (occlusive). No irritation was seen after exposure for 1 or 5 minutes, but after 15 minutes a slight mottled redness occurred which was reversible after 1 week. After a 20-hour exposure, similar findings were recorded which were again reversible after 1 week.
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