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Physical & Chemical properties

Partition coefficient

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Administrative data

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from handbook or collection of data
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Determination of octanol water partition coefficient of the test chemical.
GLP compliance:
not specified
Type of method:
other: no data available
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
2.81
Remarks on result:
other: Other details not known
Details on results:
The logKow of test chemical was determined to be 2.81.
Conclusions:
Based on the data obtained from the various reliable sources, the partition coefficient (log Pow) value of the test chemical was determined to be 2.81, which indicates that the test chemical was hydrophilic in nature.
Executive summary:

Based on the data obtained from the various reliable sources, the partition coefficient (log Pow) value of the test chemical was determined to be 2.81, which indicates that the test chemical was hydrophilic in nature.

Description of key information

Based on the data obtained from the various reliable sources, the partition coefficient (log Pow) value of the test chemical was determined to be 2.81, which indicates that the test chemical was hydrophilic in nature.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.81

Additional information

Based on the data obtained from the various reliable sources, the partition coefficient (log Pow) value of the test chemical was determined to be 2.81, which indicates that the test chemical was hydrophilic in nature.

The octanol water partition coefficient of the test chemical was determined using the shake-flask method. In shake-flask method, a small amount of the solute is dissolved in either aqueous or organic phase, equilibrium partition is obtained by agitation, the phases are separated and one or both phases are analyzed for solute. Several different methods of agitation are used to the solvents into intimate contact. The phases separate under normal gravity they are usually centrifuged to accelerate the separated smallest droplets. Analytical method involves the use of absorption spectrophotometry with the buffered solution of pH > 7.0 and for the measurement of partition coefficient. The solid support is usually silanized diatomaceous silica. The column is loaded by pulling an unsaturated solution of the solute of interest at a known concentration onto a water-saturated octanol through the column. The solute eluted with octanol-saturated water, and the effluent is analyzed by high pressure liquid chromatography or gas liquid chromatography. The partition coefficient (log Pow) value of the test chemical was determined to be 2.61 at a temperature of 25°C and pH > 7.0, respectively. Based on this experimental value, test chemical can be considered to be hydrophilic in nature.

 

Study was conducted to determine the partition coefficient of the test chemical. The partition coefficient (log Pow) value of the test chemical was determined to be 2.99. Based on this experimental value, test chemical can be considered to be hydrophilic in nature.

 

Thus, based on the above all studies, the Log Pow value was observed to be ranges from 2.81 2.99.