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EC number: 202-805-4
CAS number: 99-97-8
Acute inhalation toxicity study was
conducted by using the given test chemical in 40 Sprague-Dawley rats at
the doses of 5.27, 1.73, 0.99, and 0.30 mg/l via inhalation route to
whole-body exposure by aerosol/vapor for 4-h period. Animals were
initially exposed to a target concentration of 5 mg/I. Test
concentrations for the three subsequent exposures were selected based on
mortality due to this initial exposure end the results of each
subsequent exposure.All rats were observed carefully for signs af
toxicity immediately after removal from the exposure chamber and at
least once per day during the 14-day observation period. To the maximum
extent possible, animals were also observed during the exposures. During
the two highest concentration exposures, most or all rats could not be
adequately observed to allow any documentation of clinical signs.All
test rats were weighed immediately before exposure, on post-exposure day
7 and just before necropsy. All test animals found dead were subjected
to gross necropsy. At the end of the 14-day observation period, all
surviving rats were euthanized following an intraperitoneal injection of
sodium pentobarbital or CO2 asphyxiation (by exsanguination) and
subjected to gross necropsy. The necropsy included examination of all
body surfaces and openings and of the external surface of the brain,
heart, lungs end respiratory tract, liver, Spleen, kidneys, adrenals,
gastrointestinal tract, gonads and urinary bladder. The gastrointestinal
tract and urinary bladder were opened and examined if lesions were
observed. Mortality occurred as – At 5.27 mg/l – All animals found dead;
At 1.73 mg/l – 3 males and 5 females found dead and no mortality was
observed at 0.30 and 0.99 mg/l.Clinical signs in rats exposed to 1.73
mg/l included hypo activity, a comatose / prostrate condition, dyspnea
or rapid respiration and salivation. Other incidental signs observed for
some animals from this group included urine stains, eye discharge,
ptosis, limb paralysis, nasal discharge, red material around the nose
and red material around the eyes. The most frequently observed signs in
rats exposed to 0.99 or 0.30 mg/l were nasal discharge and red material
around the nose. Two male rats and one female rat from the 0.30 mg/l
group were also reported to have dyspnea immediately after the exposure.
Rats exposed to one of the two lower concentrations were free of signs
by 1-2 days post-exposure.For the 5.27, 1.73, 0.99 and 0.30 mg/!
exposure groups, MEAN pre-exposure body weights ranged from 137 to 262 g
for male rats and 169 to 1392 g for female rats.
For male survivors of exposure to 1.72
mg/l and male and female Survivors of exposure to 0.99 or 0.20 mg/l (all
rats), weight gain was observed during both the first and second weeks
of the observation period. Mean cumulative weight gain ranged from 73 to
91 g for male rats and 28 to 33 g for female rats. No gross lesions were
found in animals exposed to 0.99 or 0.30 mg/l. In rats exposed to the
two higher concentrations, mottled lungs and red ovaries were frequently
found and may have been exposure-related. Several rats from these groups
also had gas-filled gastrointestinal organs. A few other lesions were
observed in individual rats, but were not considered to be
toxicologically significant. Under the condition of the study, the LC50
value was considered to be 1.4 mg/L (1400 mg/m3), when 40 male and
female Sprague-Dawley rats were treated with the given test chemical via
inhalation route to whole-body exposure by aerosol/vapor for 4-h period.
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