Registration Dossier
Registration Dossier
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EC number: 202-849-4 | CAS number: 100-41-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals.
Data source
Reference
- Reference Type:
- publication
- Title:
- TOXICITY STUDIES of ETHYLBENZENE (CAS No. 100-41-4) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES).
- Author:
- NTP
- Year:
- 1 992
- Bibliographic source:
- NATIONAL TOXICOLOGY PROGRAM March 1992 NTP TOX 10 NIH Publication No. 92-3129 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service, National Institutes of Health.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Ethylbenzene
- EC Number:
- 202-849-4
- EC Name:
- Ethylbenzene
- Cas Number:
- 100-41-4
- Molecular formula:
- C8H10
- IUPAC Name:
- ethylbenzene
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CB6F1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Duration of treatment / exposure:
- 13-Week
Results and discussion
Any other information on results incl. tables
Study observed:No induction of micronuclei in peripheral blood erythrocytes of male and female mice.
Applicant's summary and conclusion
- Conclusions:
- Ethylbenzene did not induce micronuclei in peripheral blood erythrocytes of male and female mice at the test conditions.
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