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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
review article or handbook
Title:
Range-finding toxicity data: List VI.
Author:
Smyth, Jr. HF, Carpenter, CP, Weil, CS, Pozzani, UC, and Striegel, JA
Year:
1962
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 23:95-107

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Handbook data
Principles of method if other than guideline:
Handbook data: Acute Inhalation Exposure
GLP compliance:
not specified
Test type:
other: Handbook data

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
ethylbenzene

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body

Results and discussion

Any other information on results incl. tables

LC50 (rat, 4-hour) = 4000 ppm (17.4 mg/l).

Applicant's summary and conclusion

Conclusions:
The cut-off value for classification of substances for acute inhalation toxicity for vapours is LC50= 20 mg/L. The published data for ethylbenzene report LC50 values lower than 20 mg/L which correspond to Acute Tox. 4; H332: Harmful if inhaled.