Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
review article or handbook
Title:
Range-finding toxicity data: List VI.
Author:
Smyth, Jr. HF, Carpenter, CP, Weil, CS, Pozzani, UC, and Striegel, JA
Year:
1962
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 23:95-107

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Handbook data
Principles of method if other than guideline:
Handbook data: Acute Inhalation Exposure
GLP compliance:
not specified
Test type:
other: Handbook data

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
ethylbenzene

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body

Results and discussion

Any other information on results incl. tables

LC50 (rat, 4-hour) = 4000 ppm (17.4 mg/l).

Applicant's summary and conclusion

Conclusions:
The cut-off value for classification of substances for acute inhalation toxicity for vapours is LC50= 20 mg/L. The published data for ethylbenzene report LC50 values lower than 20 mg/L which correspond to Acute Tox. 4; H332: Harmful if inhaled.