Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals.

Data source

Reference
Reference Type:
review article or handbook
Title:
Sax's Dangerous Properties of Industrial Materials.
Author:
Lewis, R.J.
Year:
1996
Bibliographic source:
9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Handbook data
Principles of method if other than guideline:
Handbook data: Acute toxicity; Dermal
GLP compliance:
not specified
Test type:
other: Handbook data

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
ethylbenzene

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Results and discussion

Any other information on results incl. tables

LD50 (rabbits) =17800 mg/kg bw.

Applicant's summary and conclusion

Conclusions:
The cut-off value for classification of substances for acute dermal toxicity is LD50= 2000 mg/kg. The published data for ethylbenzene report LD50 values higher than the cut off for classification.