Registration Dossier
Registration Dossier
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EC number: 200-854-6 | CAS number: 75-25-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental Phase: 08 January 2018 to 29 June 2018. Report Issued: 28 August 2018.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.16
- Temp.:
- 30 °C
- pH:
- 6.6
- Key result
- Type:
- Pow
- Partition coefficient:
- 145
- Temp.:
- 30 °C
- pH:
- 6.6
- Conclusions:
- The partition coefficient of the test item was determined to be 145, log10 Pow 2.16.
- Executive summary:
Introduction
The partition coefficient of the test substance was determined using a high performance liquid chromatography (HPLC) method. The method was designed to be compatible with the following guidelines:
- Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008
- Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004
Method
The test system consisted of a high performance liquid chromatograph with an appropriate detector. A reverse phase HPLC column with a very low percentage of polar groups was used and the mobile phase contained at least 25% aqueous phase. Prior to the HPLC test a preliminary estimate was calculated based on fragment constant methodology using KOWWIN v1.68 (September 2010), © 2000 U.S. Environmental Protection Agency,
Results and Conclusion
The partition coefficient of the test item was determined to be 145, log10 Pow 2.16.
Reference
The retention times, capacity factor and log10 Pow value determined for the sample are shown in the following table:
| Injection | Retention Time (mins) |
Capcity Factor (K') |
Log10 K' | Log10 Pow |
| 1 | 4.384 | 1.296 | 0.113 | 2.16 |
| 2 | 4.384 | 1.296 | 0.113 | 2.16 |
Mean log10 Pow: 2.16
Partition coefficient: 145
Description of key information
Log10 Pow value for the test substance using the HPLC method.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.16
- at the temperature of:
- 30 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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