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EC number: 200-854-6
CAS number: 75-25-2
Acute toxicity of the test substance.
The acute oral toxicity of the test
substance to Sprague-Daawley rats. No guideline was followed but the
study used a method similar to the classical LD50 test.
To establish the dose levels to be used
groups of two animals were administered test compounds at 250-3000 mg/kg
and the mortality data were recorded and used ot det dosew in the main
test. For the main test five doses between 546 and 2100
mg/kg were employed and 10 males and 10 females used at each dose level.
Dosing solutions were administered to animals in corn oil using
premature infant feeding tubes (8 Fr., 15 in. length) at a maximum
volume of 2ml/kg. Clinical observations were made for 14 days after
dosing and a post-mortem examination was performed on animals which died
during this period. All surviving animals were killed at the end of 14
days and subjected to gross pathologic examination.
The acute oral LD50 of the test substance in
Sprague-Dawley rats was 1388 and 1147 mg/kg bw in males and females
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