Registration Dossier
Registration Dossier
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EC number: 246-836-1 | CAS number: 25321-14-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliability as cited in OECD SIDS Dinitrotoluene (isomers mixture) CAS No.: 25321-14-6, 2004. Meets generally accepted scientific standards, documentation limited, acceptable for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Rabbits were treated under occlusive conditions with dinitrotoluene.
Deviations to OECD 404 Guideline Study: No. of animals (2 instead of 3), 24h exposure, occlusive coverage - GLP compliance:
- no
Test material
- Reference substance name:
- Dinitrotoluene
- EC Number:
- 246-836-1
- EC Name:
- Dinitrotoluene
- Cas Number:
- 25321-14-6
- Molecular formula:
- C7H6N2O4
- IUPAC Name:
- Reaction mass of 1-methyl-2,4-dinitrobenzene and 2-methyl-1,3-dinitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): dinitrotoluene
- Analytical purity: ca. 80% 2,4-DNT and 20& 2,6-DNT
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: interior side of right ear
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg as an aqueous paste - Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 d (examination time points 0, 48 hours and 72 hours)
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: interior side of right ear
- Type of wrap if used: plaster
REMOVAL OF TEST SUBSTANCE
- Washing (if done): water and soap/oil
- Time after start of exposure: 24 h
SCORING SYSTEM:
Scoring of erythema and oedema.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: all examination time points
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: all examination time points
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
Any other information on results incl. tables
Score of 0 for all observation time points (no details on scoring system).
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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