Registration Dossier
Registration Dossier
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EC number: 246-836-1 | CAS number: 25321-14-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 Feb - 24 Feb 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliability as cited in OECD SIDS Dinitrotoluene (isomers mixture) CAS No.: 25321-14-6, 2004. Meets generally accepted scientific standards, well documented and acceptable for assessment; pure 2,4-DNT
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
- Reference Type:
- secondary source
- Title:
- Dinitrotoluene (isomers mixture), CAS No.: 25321-14-6
- Author:
- OECD SIDS
- Year:
- 2 004
- Bibliographic source:
- OCED SIDS
Materials and methods
- Principles of method if other than guideline:
- according to Noakes and Sanderson, Brit. J. Industr. Med. 26, 59 (1969), 5 rats/dose/group, post- exposure observation time: 14 d
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4-dinitrotoluene
- EC Number:
- 204-450-0
- EC Name:
- 2,4-dinitrotoluene
- Cas Number:
- 121-14-2
- Molecular formula:
- C7H6N2O4
- IUPAC Name:
- 1-methyl-2,4-dinitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 2,4-dinitrotoluene
- Analytical purity: pure
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- either 4 or 24 h (no detailed data available)
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed several time at the day of application and twice daily thereafter. Body weights were recorded at application and after 14 days.
- Necropsy of survivors performed: yes; spot-checked
- Other examinations: clinical signs and gross pathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
Any other information on results incl. tables
No deaths occured. No signs of intoxication were recorded and no changes in gross pathology were observed.
Applicant's summary and conclusion
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