Registration Dossier
Registration Dossier
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EC number: 246-836-1 | CAS number: 25321-14-6
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference in foreign language (Chinese), only Englisch abstract
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effect of dinitrotoluene (DNT) on immune function of red cells in rats.
- Author:
- Wu, H. et al.
- Year:
- 2 000
- Bibliographic source:
- Gongye Weisheng Yu Zhiyebing 26, 88-89.
- Reference Type:
- secondary source
- Title:
- Dinitrotoluene (isomers mixture), CAS No.: 25321-14-6
- Author:
- OECD SIDS
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Study performed to investigate the effects of DNT on immune function of red blood cells.
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- immunotoxicity
Test material
- Reference substance name:
- Dinitrotoluene
- EC Number:
- 246-836-1
- EC Name:
- Dinitrotoluene
- Cas Number:
- 25321-14-6
- Molecular formula:
- C7H6N2O4
- IUPAC Name:
- Reaction mass of 1-methyl-2,4-dinitrobenzene and 2-methyl-1,3-dinitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): DNT 80/20 (ca. 80% 2,4-DNT and ca. 20% 2,6-DNT)
- Analytical purity: 99.6%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90 d
- Frequency of treatment:
- daily
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5, 16 and 50 mg/kg bw/d
Basis:
actual ingested
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- yes, concurrent vehicle
Results and discussion
- Details on results:
- The daily dose of 50 mg/kg bw led to a disturbances of the immune function of red cells.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
